Ideally, skin should feel soft and smooth; more importantly however we need our skin to protect us from UV damage, free radicals and hazardous microorganisms while simultaneously providing barrier protection from various chemicals and liquids. The epidermis is actually part of our innate immune system and serves as one of the body’s primary defense mechanisms to protect us from an onslaught of environmental stimuli. Yet the ability of the epidermis to fulfill all of these functions tends to diminish if it is not properly hydrated, so the way we like our skin to look and feel is also optimal for its function. AC Moisture-Plex Advanced PF is formulated to address all of these issues by improving barrier integrity, reducing evaporation, improving moisture balance (with 24 hour moisturization efficacy), and maintaining lipid balance all while increasing cellular renewal. There are a multitude of ways for our skin to become dry, which results in irritation, damage and loss of function. We have to worry about more than just cold temperatures, changes in humidity and the wind drying out our skin, and often the products we use can cause the same drying effect. Soap, facial cleansers and toners are notorious for dehydrating our skin, and ironically due to the alcohol content, some moisturizers can actually cause the same effect. The epidermis consists of several layers with the outermost layers being keratinized cells held together by epidermal lipids. Secreted on the surface is a layer of sebum that provides moisturizing benefits. When the skin becomes dry, the layer of sebum is often stripped away, and the integrity of the epidermal lipids is less substantive. The keratinized cells separate and the skin becomes itchy and usually appears red, inflamed and cracked. With a plethora of efficacy supporting moisturization, enhanced barrier protection, and increased cellular renewal AC Moisture-Plex Advanced PF is an ideal ingredient for personal care products marketed toward protecting the skin for optimal function.
Improvements In Moisturization over time... Read More
As evidenced in a 4 week efficacy study of AC Moisture-Plex Advanced PF on skin, moisture levels were improved by 51.92% after 24 hours and by 61.28% after 4 weeks when compared to the untreated control. When compared to the base cream AC Moisture-Plex Advanced PF improved moisturization 17.83% better after 24 hours. After 4 weeks AC Moisture-Plex Advanced PF improved moisturization levels 44.30% better than the base lotion alone. Results indicate that AC Moisture-Plex Advanced PF is capable of increasing moisturization when compared to both the untreated control as well as the base lotion.
Measures an increase in moisture to determine an increase in conductance... Read More
According to the results, the most effective level of AC Moisture-Plex Advanced PF after 24 hours is the 5.0% use level. AC Moisture-Plex Advanced PF still shows an increase at all 3 use levels after 24 hours from initial application. From these results, we can determine that here is an increase in moisture, as an increase in conductance represents a direct correlation.
Assesses a product's moisturization benefits compared to Hyaluronic Acid... Read More
Measurements taken at 30 minutes and 2, 4, 6, and 8 hour increments showed that over these periods of time, 5.0% AC Moisture-Plex Advanced PF increased skin moisturization by an average of 61.0%, 41.0%, 21.0% 25.0% and 30.0% respectively. The 0.1% Hyaluronic Acid
￼test sites yielded increased moisture levels by 13.0%, 11.0%, 0.0%, 5.0% and 10.0% when measured at the same time increments. The skin patches where 0.2% Hyaluronic Acid was applied also resulted in moisture levels lower than those found at the AC Moisture-Plex Advanced PF sites, increase moisture levels by 11.0%, 10.0%, 3.0% 5.0% and 14.0% at the 2, 4, 6 and 8 hour time marks, respectively.
Measures a material's potential to protect against oxidative stress or ROS... Read More
AC Moisture-Plex Advanced PF exhibited antioxidant activity comparable to 200μM Trolox®. The antioxidant capacity of AC Moisture-Plex Advanced PF increased as the concentration increased, as a result we can assure that its ability to minimize oxidative stress is dose dependent.
Measures reduction of inflammatory response... Read More
AC Moisture-Plex Advanced PF exhibited anti-inflammatory effects on LPS-treated fibroblasts. This decrease in IL-6 production indicates a reduced inflammatory environment which could decrease the signs of aging and reduce the formation of fine lines and wrinkles.
Assesses wound healing properties of in vitro cultured human dermal fibroblasts... Read More
AC Moisture-Plex Advanced PF was able to increase cell migration and close the scratch at a rate comparable to the positive control. The mechanisms of the cells in the in-vitro scratch assay mimic the mechanisms seen in in-vivo wound healing. It can therefore be concluded that at normal use concentrations AC Moisture-Plex Advanced PF enhances healing and cell proliferation properties.
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