Phyto-Biotics Perilla capitalizes on specific activity of the phenolic metabolite, Rosmarinic Acid, produced by Perillia frutescens, or Chinese Basil, to provide the cosmetic market with a plant-derived, stem cell ingredient designed to impart antioxidant, protectant, antimicrobial and anti-aging benefits while enhancing cellular metabolism and improving radical stability. The secondary metabolites produced during times of stress have supplied Perilla frutescens with potent antioxidant and soothing properties, helping lessen systemic damage caused by free radicals and resist impending inflammation. Of particular interest, the phenolic compound, Rosmarinic Acid has demonstrated antimicrobial and antioxidant properties. Rosmarinic Acid strongly inhibits 5-lipoxygenase products, 5-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) and Leukotriene A4 (LTB4) at concentrations of 10-5 and 10-3M. In addition to Rosmarinc Acid, inhibition of 5-HETE and LTB4 were exhibited to a degree in the subsequent, following order: Caffeic Acid, Caffeoyltartaric Acid, Caffeoylmalic Acid, and Chlorogenic Acid. Furthermore, an added benefit of Rosmarinic Acid is that it provides antibacterial activity, specifically against Bacillus subtilis, Micrococcus luteus, and Escherichia coli. These aforementioned benefits imply that Rosmarinc Acid has potential as a therapeutic treatment for allergic reactions or inflammation and an antimicrobial. In order to sustainably source the necessary phenolic metabolite, Rosmarinic Acid, Active Concepts grows Perilla frutescens in cell culture. Using biotic stress, specifically pathogenic stress via Leuconostoc sp., our formulators created Phyto-Biotics Perilla by inducing the production of the phenolic compound, Rosmarinic Acid, to create a plant stem cell product ideal for anti-aging, antimicrobial and soothing cosmetic applications.
Assesses the ability of a sample to increase cellular metabolic activity in cult... Read More
￼Phyto-Biotics Perilla exhibited positive results by increasing cell metabolism. The increase in fluorescent signal indicates an increase in cellular metabolism and viability post Phyto-Biotics Perilla treatment.
Measures a material's potential to protect against oxidative stress or ROS... Read More
Phyto-Biotics Perilla exhibited antioxidant activity comparable to 200μM Trolox®. The antioxidant capacity of Phyto-Biotics Perilla increased as the concentration increased, as a result we can assure that its ability to minimize oxidative stress is dose dependent.
Measures reduction of inflammatory response... Read More
Phyto-Biotics Perilla exhibited anti-inflammatory effects on LPS-treated fibroblasts. As expected, the changes in IL-6 production using Phyto- Biotics Perilla appears to be dose dependent. This decrease in IL-6 production indicates a reduced inflammatory environment which could decrease the signs of aging and reduce the formation of fine lines and wrinkles.
Increase and sustained skin moisturization... Read More
As evidenced in a 4 week efficacy study of Phyto-Biotics Perilla on skin, moisture levels were improved by 74.2% after 24 hours and by 143.6% after 4 weeks when compared to the untreated control. Comparisons of the base lotion to the Experimental Lotion containing 2.0% Phyto-Biotics Perilla demonstrate the experimental material moisturized the skin 21.0% better after 24 hours. After four weeks the base lotion containing 2.0% Phyto-Biotics Perilla moisturized skin 48.3% better than the base lotion alone.
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