The demand for stem cell technologies has grown exponentially in the last decade. Trending, specifically in the cosmetic industry, current stem cell technologies utilize Meristematic cells, non-differentiating plant stem cells from simple cell extracts with no specific activity. To propel beyond the current offerings on the market, Active Concepts has chosen to use biotic stress, embodied by the sustainable practice of co-culturing plant stem cells with Pseudomonas sp., to promote the formation of secondary metabolites. This novel approach induces cellular differentiation and provides formulators with the ability to finely customize formulations, specify activity and skin benefits while offering brand distinction. Phyto-Biotics Quercus® capitalizes on specific activity of the phenolic metabolites produced by Quercus alba, or White Oaks, to provide the cosmetic market with a plant-derived, stem cell ingredient designed to impart antioxidant, soothing, antimicrobial and anti-aging benefits while enhancing cellular metabolism. Due to this trees ability to grow in a variety of environments, White Oaks are susceptible to pathogenic stress like fungi and insects. This is no match for the White Oak, which continues to flourish as a result of the secondary metabolites that have allowed this oak to evolve and ward off potential threats. White Oak Bark has high constituents of the phenolic compounds, tannins and quercin. With potent astringent properties, White Oak Bark Extract is known to help absorb toxins and sooth irritated, swollen skin. With natural antimicrobial properties, White Oak Bark Extracts are often used in topical applications to treat skin issues, specifically bacterial and viral infections. Using solvent extraction from a naturally grown, whole plant is environmentally damaging. In order to sustainably source the necessary phenolic metabolites, sourced from tannic acid, Active Concepts grows Quercus alba, or White Oaks, in cell culture. Using biotic stress, specifically pathogenic stress via Leuconostoc sp., our formulators created Phyto-Biotics Quercus® by inducing the production of tannic acid to create a plant stem cell product ideal for anti-aging cosmetic applications.
Assesses the ability of a sample to increase cellular metabolic activity in cult... Read More
￼Phyto-Biotics Quercus exhibited positive results by increasing cell metabolism. The increase in fluorescent signal indicates an increase in cellular metabolism and viability post Phyto-Biotics Quercus treatment.
Improves skin density... Read More
As evidenced in a 4 week efficacy study of Phyto-Biotics Quercus, skin density showed a steady improvement over 4 weeks when compared to the untreated control and the base lotion. When compared to the base cream, Phyto-Biotics was more effective in improving skin density at the end of each test week. Results indicate that Phyto-Biotics Quercus is capable of consistently increasing collagen levels and skin density over time, in comparison to the base lotion which demonstrated lower or steady collagen levels each week in comparison to the initial reading.
Measures reduction of inflammatory response... Read More
Phyto-Biotics Quercus exhibited anti-inflammatory effects on LPS-treated fibroblasts. As expected, the changes in IL-6 production using Phyto- Biotics Quercus appears to be dose dependent. This decrease in IL-6 production indicates a reduced inflammatory environment which could decrease the signs of aging and reduce the formation of fine lines and wrinkles.
Increase and sustained skin moisturization... Read More
As evidenced in a 4 week efficacy study of Phyto-Biotics Quercus on skin, moisture levels were improved by 17.63% after 24 hours and by 146.98% after 4 weeks when compared to the untreated control. Comparisons of the base lotion to the Experimental Lotion containing 2.0% Phyto-Biotics Quercus demonstrate the experimental material moisturized the skin 8.10% better after 24 hours. After two weeks the base lotion containing 2.0% Phyto-Biotics Quercus moisturized skin 44.69% better than the base lotion alone and was 29.30% more moisturizing than the base lotion after 4 weeks.
Measures a material's potential to protect against oxidative stress or ROS... Read More
Phyto-Biotics Quercus exhibited antioxidant activity comparable to 200μM Trolox®. The antioxidant capacity of Phyto-Biotics Quercus increased as the concentration increased, as a result we can assure that its ability to minimize oxidative stress is dose dependent.
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