Phytofuse Renew®

A functional, active ingredient that improves the slip and cushion in finished formulations, Phytofuse Renew® soothes the skin and provides benefits such as moisturization and protection. This product, which imparts an immediate cooling sensation when applied, simultaneously enhances cellular proliferation to aid in wound healing. In hair care, Phytofuse Renew® increases the sheen of the hair while hydrating and providing antioxidant protection against environmental stressors.

Efficacy Assays

  • Assessment of Hair Characteristics

    Assesses a set of parameters subjectively rated by volunteers... Read More

  • Assessment of Hair Characteristics

    The results of the assessment indicate that when incorporated into a serum, Phytofuse Renew® is capable of subjectively improving hair characteristics over all by 11% when compared to untreated hair and by 25% when being compared to the control serum. The only characteristic perceived to be positive when using the control serum was the increase in shine, however, it was rated 11% worse than completely untreated hair. Phytofuse Renew® imparts benefits that tactilely and visually improve the sensorial assessment of typically curly, unruly or frizzy hair. This aqueous product is ideal for use in hair care formulations, especially as a replacement for silicones, to increase shine, smooth the cuticle, and moisturize the hair for a healthier appearance.

  • Cellular Viability Assay

    Assesses the ability of a sample to increase cellular metabolic activity in cult... Read More

  • Cellular Viability Assay

    Phytofuse Renew® exhibited positive results by increasing cell metabolism. The increase in fluorescent signal indicates an increase in cellular metabolism and viability post Phytofuse Renew® treatment. For these reasons, we can assume Phytofuse Renew® is suitable for cosmetic applications designed to increase cell viability and metabolism.

  • High Resolution Skin Imaging Ultrasound Assay

    Improves skin density... Read More

  • High Resolution Skin Imaging Ultrasound Assay

    As evidenced in a 4 week efficacy study of Phytofuse Renew® on skin, skin density was improved by 32.82% after 24 hours and by 40.10% after 4 weeks when compared to the untreated control. When compared to the base cream Phytofuse Renew® improved skin density by 17.29% after 24 hours and after 4 weeks Phytofuse Renew® improved density by 25.60%. Results indicate that Phytofuse Renew® is capable of improving skin density when compared to both the untreated control as well as the base lotion. Phytofuse Renew® has a positive effect on skin’s density when used at recommended use levels.

  • IL-6 ELISA Assay

    Measures reduction of inflammatory response... Read More

  • IL-6 ELISA Assay

    Phytofuse Renew® exhibited anti-inflammatory effects on LPS-treated fibroblasts. As expected, the changes in IL-6 production using Phytofuse Renew® appear to be dose dependent. This decrease in IL-6 production indicates a reduced inflammatory environment which could decrease the signs of aging and reduce the formation of fine lines and wrinkles. For these reasons, we can assume Phytofuse Renew® is suitable for cosmetic applications designed to provide soothing and anti-aging properties.

  • Moisturization Assay

    Increase and sustained skin moisturization... Read More

  • Moisturization Assay

    Results indicated that after 24 hours, the solution containing 2.0% Phytofuse Renew® moisturized the skin 17% more effectively than the base lotion alone, while enhancing hydration levels 26% better than the base lotion alone after three weeks of application. When comparing the emulsion containing 2.0% Phytofuse Renew® to the untreated skin site, moisture levels increased by 71% after 24 hours and remained elevated by 95% at the end of the three week testing period.

  • ORAC Assay

    Measures a material's potential to protect against oxidative stress or ROS... Read More

  • ORAC Assay

    As shown in figure 1, Phytofuse Renew® exhibited antioxidant activity comparable to our known antioxidant, Trolox®. The antioxidant capacity of Phytofuse Renew increased as the concentration increased, as a result we can assure that its ability to minimize oxidative stress is dose dependent. Phytofuse Renew® was designed to provide moisturizing, antioxidant, and soothing properties. With the present study we can confirm that this unique ingredient is not only capable of providing functional benefits but it is also capable of providing antioxidant benefits when added to cosmetic applications.

  • Transepidermal Water Loss

    Improves skin integrity and barrier function... Read More

  • Transepidermal Water Loss

    Results indicate continuous improvements in the barrier of the skin throughout the 3 week test period. After one week, the solution containing 2.0% Phytofuse Renew® decreased TEWL 12% more effectively than the base lotion alone. After three weeks, the solution containing 2.0% Phytofuse Renew® demonstrated even more effective barrier protection, decreasing TEWL 19% better than the base lotion alone.

  • Scratch Assay

    Assesses wound healing properties of in vitro cultured human dermal fibroblasts... Read More

  • Scratch Assay

    Phytofuse Renew® was able to increase cell migration and close the scratch at a rate comparable to the positive control. The mechanisms of the cells in the in vitro scratch assay mimic the mechanisms seen in in vivo wound healing therefore we can be assured that our results are translatable outside the laboratory. Phytofuse Renew® was designed to be moisturizing and soothing, and provide enhanced aesthetics. With the present study we can also be confident that this product has healing abilities and cell proliferation properties.

Product Information

Product Code
16586
INCI Name
Selaginella Lepidophylla Extract
INCI Status
Approved
Source
Botanical
Potential Applications
Skin, Hair, Decorative Cosmetics
Suggested Use Levels
1.0 - 10.0%
Solubility
Water Soluble
Solvent
Water
Benefits
Moisturizing, Antioxidant, Aesthetic Modifier, Soothing, Wound Healing, Reduces TEWL, Enhances Barrier Function, Sensorial
Preservation System
Preservative Free

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