As we know, aesthetic perfection is now the consumer standard. The appearance of uneven skin is associated with apparent and visual signs of aging. Traditional skin lightening products have been surrounded by negative press, reporting skin irritation and lackluster results, which have triggered doubt with consumers. However, this long standing aesthetic standard of fair and flawless skin, stemming from Asia, has transformed the cosmetic market, leaving consumers searching for the answer to a brighter, more radiant complexion. Active.Lite® is a naturally potent and sustainable, rapid skin lightening product with an innovative, patent-pending mechanism of action. Active Concepts has heavily invested in the modern study of the cross talk between microflora and the human body. With saying this, we looked at yeast grown on different biomasses, with particular attention to the bio-transformation of the phytochemicals present, and their ability to inhibit melanogenesis. We discovered the product that came out the strongest was yeast based on Vitis Vinifera. With further investigation, we found that the mechanism of action responsible for hypopigmentation, was through Histamine 3 Receptor (H3R) Antagonism. Through a series of In-vitro and In-vivo testing, we can infer that Active.Lite® represses the transcription of melanogenic genes through the inhibition of the upstream melanogenesis response and reduces inflammatory effects. An even skin tone and minimization of dark spots can be achieved through this modern pathway of skin lightening for that everlasting, flawless complexion. Using the efficacy results of each skin lightening product, their use level and respective costs to calculate the efficacy per use level percentage plus the cost contribution of each material, we determined the efficiency of each product as a ratio of efficacy per dollar spent. Active.Lite® has the cost contribution of 13% and Arbutin has the cost contribution of 2.0%. This is the percentage of efficiency you get per dollar spent. When looking at the percent difference there is a 92.0% percent difference of efficiency delivered per dollar spent.
Assesses the ability of a sample to increase cellular metabolic activity in cult... Read More
￼Active.Lite® was tested to evaluate its effects on the viability of normal human dermal fibroblasts (NDHF). At concentrations of both 0.1% and 0.01%, Active.Lite® did not exhibit any inhibition on cell viability. It can therefore be concluded that at normal use concentrations Active.Lite® is not cytotoxic.
Visual evaluation of product's ability to lighten and even skin tone... Read More
Through this in-vivo photo comparison, we are able to determine that Active.Lite® is capable of producing visibly rapid skin lightening and tone evening results in under 14 days. These demonstrated results showcase Active.Lite® as the product for reducing the appearance of dark spots and other hyperpigmentation on hands, face, and décolleté without irritation.
Inhibits melanin synthesis, in vitro or in vivo... Read More
Active.Lite® was able to inhibit melanin production by 93.58% when using the product at a 0.1% concentration. We also evaluated Active.Lite’s® ability to inhibit melanogenesis in comparison to Kojic Acid, Arbutin and AA2G. These materials are used in other cosmetic products all over the world. Active.Lite® was able to inhibit melanin production by 93.58%, making it 51.77% more effective than Kojic Acid, 88.23% more effective than Arbutin, and 66.67% more effective than AA2G.
Inhibits tyrosinase in vitro indicating reduction of hyperpigmentation... Read More
Active.Lite® was able to inhibit tyrosinase compared to our positive control, Kojic Acid. Kojic Acid is used as a control since it is a market standard skin-lightening ingredient in the cosmetic industry. The in-vitro Tyrosinase Inhibition assay was performed using Kojic Acid and α-Arbutin as positive controls to test the efficacy of Active.Lite®. Active.Lite® inhibited tyrosinase production 52.45% more effectively than Kojic Acid and 31.78% better than α-Arbutin.
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