Phytofuse Renew^®

After one week, the solution containing 2.0% Phytofuse Renew® decreased TEWL 12% more effectively than the base lotion alone. After three weeks, the solution containing 2.0% Phytofuse Renew® demonstrated even more effective barrier protection, decreasing TEWL 19% better than the base lotion alone.

At a concentration of 2.0%, Phytofuse Renew® demonstrated significantly lower levels of MDA than the untreated controls. It can therefore be concluded that at normal use concentrations Phytofuse Renew® can be used as a hair pollution protection active ingredient.

As evidenced in a 4 week efficacy study of Phytofuse Renew® on skin, skin density was improved by 32.82% after 24 hours and by 40.10% after 4 weeks when compared to the untreated control. When compared to the base cream Phytofuse Renew® improved skin density by 17.29% after 24 hours and after 4 weeks Phytofuse Renew® improved density by 25.60%. Results indicate that Phytofuse Renew® is capable of improving skin density when compared to both the untreated control as well as the base lotion.

Phytofuse Renew®-exhibited anti-inflammatory effects on LPS-treated fibroblasts. As expected, the changes in IL-6 production using Phytofuse Renew® appear to be dose dependent. This decrease in IL-6 production indicates a reduced inflammatory environment which could decrease the signs of aging and reduce the formation of fine lines and wrinkles. For these reasons, we can assume Phytofuse Renew® is suitable for cosmetic applications designed to provide soothing and anti-aging properties.

Moisture levels were improved by 59% after 24 hours and by 86% after 3 weeks when compared to the untreated control. When compared to the base cream Phytofuse Renew® improved moisturization by 15% after 24 hours and after 3 weeks Phytofuse Renew® improved moisturization by 18%. Results indicate that Phytofuse Renew® is capable of increasing moisturization when compared to both the untreated control as well as the base lotion.

Phytofuse Renew® exhibited antioxidant activity comparable to our known antioxidant, Trolox®. The antioxidant capacity of Phytofuse Renew® increased as the concentration increased, as a result we can assure that its ability to minimize oxidative stress is dose dependent.

Phytofuse Renew® was able to provide pollution protection as specified by micronized carbon residue. The small amount of carbon that remains compared to the untreated control indicates the ability of Phytofuse Renew® to provide barrier protection against everyday air pollution and slow the extrinsic aging process. It can therefore be concluded that at normal use concentrations Phytofuse Renew® can be used as a skin pollution protection active ingredient.

The results of the assessment indicate that when used in a conditioner, Phytofuse Renew® is capable of improving smoothing, dry and wet combability, anti-frizz, overall feel, shine and hydration more than the control serum.

In this study, Phytofuse Renew® SF was tested to evaluate its effects on the inhibition of lipid peroxidation of hair samples exposed to air pollution. At a concentration of 2.0%, Phytofuse Renew® SF demonstrated significantly lower levels of MDA than the untreated controls. It can therefore be concluded that at normal use concentrations Phytofuse Renew® SF can be used as a hair pollution protection active ingredient.